Druhý meraný tréning patril Nicovi Rosbergovi na Williamse. Za ním skončiliLewis Hamilton a Rubens Barrichello.
Výsledky 2. tréningu na VC Monaka:
| 1 | Nico Rosberg | Williams-Toyota | 1:15,243 | - | 45 | |
| 2 | Lewis Hamilton | McLaren-Mercedes | 1:15,445 | + 0,202 | 35 | |
| 3 | Rubens Barrichello | Brawn-Mercedes | 1:15,590 | + 0,347 | 41 | |
| 4 | Jenson Button | Brawn-Mercedes | 1:15,774 | + 0,531 | 36 | |
| 5 | Felipe Massa | Ferrari | 1:15,832 | + 0,589 | 42 | |
| 6 | Sebastian Vettel | Red Bull-Renault | 1:15,847 | + 0,604 | 33 | |
| 7 | Heikki Kovalainen | McLaren-Mercedes | 1:15,984 | + 0,741 | 45 | |
| 8 | Kimi Räikkönen | Ferrari | 1:15,985 | + 0,742 | 43 | |
| 9 | Kazuki Nakajima | Williams-Toyota | 1:16,260 | + 1,017 | 43 | |
| 10 | Nelson Piquet | Renault | 1:16,286 | + 1,043 | 43 | |
| 11 | Fernando Alonso | Renault | 1:16,552 | + 1,309 | 39 | |
| 12 | Mark Webber | Red Bull-Renault | 1:16,579 | + 1,336 | 27 | |
| 13 | Adrian Sutil | Force India-Mercedes | 1:16,675 | + 1,432 | 38 | |
| 14 | Jarno Trulli | Toyota | 1:16,915 | + 1,672 | 43 | |
| 15 | Sébastien Buemi | Toro Rosso-Ferrari | 1:16,983 | + 1,740 | 48 | |
| 16 | Sébastien Bourdais | Toro Rosso-Ferrari | 1:17,052 | + 1,809 | 48 | |
| 17 | Nick Heidfeld | BMW Sauber | 1:17,109 | + 1,866 | 40 | |
| 18 | Timo Glock | Toyota | 1:17,207 | + 1,964 | 45 | |
| 19 | Giancarlo Fisichella | Force India-Mercedes | 1:17,504 | + 2,261 | 45 | |
| 20 | Robert Kubica | BMW Sauber | 2 |